Thomas Opladen Selected Research

vanillactic acid

9/2020

Semi-quantitative detection of a vanillactic acid/vanillylmandelic acid ratio in urine is a reliable diagnostic marker for aromatic L-amino acid decarboxylase deficiency.

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Thomas Opladen Research Topics

Disease

7	Dystonia (Limb Dystonia) 01/2022 - 12/2011
7	Aromatic amino acid decarboxylase deficiency 01/2021 - 01/2017
6	Dopa-responsive Dystonia 01/2022 - 12/2010
5	due to Sepiapterin Reductase Deficiency Dopa-Responsive Dystonia 11/2021 - 11/2012
5	Phenylketonurias (Phenylketonuria) 11/2017 - 06/2005
4	Neurodevelopmental Disorders 01/2022 - 01/2020
4	Rare Diseases (Rare Disease) 01/2022 - 09/2014
4	Movement Disorders (Movement Disorder) 01/2021 - 11/2012
4	B BH4-Deficient Hyperphenylalaninemia 03/2013 - 06/2011
3	Parkinsonian Disorders (Parkinsonism) 01/2022 - 06/2012
3	succinic semialdehyde dehydrogenase deficiency 11/2021 - 01/2020
3	Inborn Genetic Diseases (Disease, Hereditary) 09/2021 - 11/2017
3	Muscle Hypotonia (Hypotonia) 01/2021 - 01/2015
3	Nervous System Diseases (Neurological Disorders) 01/2021 - 05/2005
3	Seizures (Absence Seizure) 12/2017 - 11/2012
3	Metabolic Diseases (Metabolic Disease) 01/2017 - 11/2016
2	autosomal recessive Segawa syndrome 01/2021 - 01/2021
2	Parkinson Disease (Parkinson's Disease) 01/2021 - 09/2014
2	Dyskinesias (Dyskinesia) 01/2020 - 06/2012
2	Hyperammonemia 12/2017 - 01/2016
2	Dystonic Disorders (Writer's Cramp) 12/2017 - 06/2012
1	Epilepsy (Aura) 01/2022
1	Brain Diseases (Brain Disorder) 01/2021
1	Mevalonate Kinase Deficiency 01/2021
1	Congenital Abnormalities (Deformity) 11/2020
1	Silver-Russell Syndrome 11/2020
1	Muscle Spasticity (Spastic) 01/2020
1	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2020
1	Methylenetetrahydrofolate reductase deficiency 01/2020
1	Guanidinoacetate methyltransferase deficiency 01/2020
1	Vomiting 01/2020
1	Gyrate Atrophy 01/2020
1	Microcephaly 12/2017
1	Reinfection 12/2017
1	Atrophy 12/2017
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 12/2017
1	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2017
1	Cognitive Dysfunction 07/2017
1	Neurodegeneration with brain iron accumulation (NBIA) 07/2017
1	Paraparesis 07/2017
1	Hypermethioninemia 01/2017
1	Glutaric Acidemia I 01/2017
1	Ornithine Carbamoyltransferase Deficiency Disease 01/2016
1	Hypothyroidism 01/2015
1	Aspartylglucosaminuria 01/2014

Drug/Important Bio-Agent (IBA)

9	Neurotransmitter Agents (Neurotransmitter)IBA 11/2021 - 11/2012
8	Dopamine (Intropin)FDA LinkGeneric 01/2022 - 12/2011
5	Levodopa (L Dopa)FDA LinkGeneric 01/2022 - 06/2012
5	Serotonin (5 Hydroxytryptamine)IBA 01/2020 - 12/2011
5	Guanosine Triphosphate (GTP)IBA 01/2020 - 12/2011
4	sapropterin (tetrahydrobiopterin)FDA Link 01/2022 - 06/2005
4	EnzymesIBA 11/2020 - 06/2011
3	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 11/2021 - 06/2011
3	Aromatic-L-Amino-Acid DecarboxylasesIBA 09/2021 - 01/2021
3	Phenylalanine (L-Phenylalanine)FDA Link 03/2013 - 12/2010
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 11/2021 - 09/2014
2	gamma-Aminobutyric Acid (GABA)IBA 11/2020 - 01/2020
2	Butyric Acid (Butanoic Acid)IBA 11/2020 - 01/2020
2	Epinephrine (Adrenaline)FDA LinkGeneric 01/2020 - 01/2017
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2020 - 01/2017
2	Folic Acid (Vitamin M)FDA LinkGeneric 01/2020 - 05/2005
2	sepiapterin reductaseIBA 12/2017 - 03/2013
2	Pharmaceutical PreparationsIBA 01/2017 - 11/2016
2	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 09/2014 - 03/2013
2	BiopterinsIBA 11/2012 - 06/2011
2	NeopterinIBA 11/2012 - 06/2011
1	TubulinIBA 01/2022
1	Monoamine Oxidase (MAO)IBA 11/2021
1	beta 2-Glycoprotein I (Apolipoprotein H)IBA 01/2021
1	CholesterolIBA 01/2021
1	Oligodendrocyte-Myelin GlycoproteinIBA 01/2021
1	3-methoxytyrosineIBA 01/2021
1	Mevalonic Acid (Mevalonate)IBA 01/2021
1	Apolipoproteins D (Apo D)IBA 01/2021
1	purineIBA 11/2020
1	Peptide Hydrolases (Proteases)FDA Link 11/2020
1	Vanilmandelic Acid (Vanillylmandelic Acid)IBA 09/2020
1	vanillactic acidIBA 09/2020
1	Extracellular Matrix ProteinsIBA 01/2020
1	Dopamine Agonists (Dopamine Agonist)IBA 01/2020
1	Transaminases (Aminotransferases)IBA 12/2017
1	Mitochondrial DNA (mtDNA)IBA 12/2017
1	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA 11/2017
1	Proteins (Proteins, Gene)FDA Link 07/2017
1	IronIBA 07/2017
1	Coenzyme A (CoA)IBA 07/2017
1	Tryptophan (L-Tryptophan)FDA Link 01/2017
1	HydroxylysineIBA 01/2017
1	Lysine (L-Lysine)FDA Link 01/2017
1	Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)IBA 01/2017
1	S-AdenosylhomocysteineIBA 01/2017
1	S-Adenosylmethionine (Ademetionine)IBA 01/2017
1	Glutaryl-CoA DehydrogenaseIBA 01/2017
1	Urea (Carbamide)FDA LinkGeneric 01/2016
1	Growth Hormone (Somatotropin)IBA 01/2015
1	Dihydroxyphenylalanine (Dopa)IBA 01/2015
1	Biological ProductsIBA 09/2014

Therapy/Procedure

3	Therapeutics 03/2013 - 06/2012
1	Precision Medicine 01/2022
1	Denervation 09/2014